What Is VDR?


VDR is a gene that encodes a protein that acts as a receptor for vitamin D that regulates bone formation and calcium absorption. A variant of the gene called rs2228570 (FokI polymorphism), is associated with a decrease in bone mineral density in white prepubertal girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the temporal and reciprocal pattern of off- and on- occupancy of the VDRE by the two components, and it is influenced by chromosomal locations and by binding preferences for specific hormones. Microarray studies on human cells show that over 100 genes contain a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual dataroom (VDR) is an archive of data and documents that are relevant to legal, business transactions or processes. Viewing, downloading or printing are not permitted. It makes use of central servers and an extranet connection that is an Internet connection that has restricted access to allow controlled access to users at specific times when users can view the data and documents.

Companies and investment banks that are involved in mergers and acquisitions are among the most frequent users of VDRs. VDR. They require an efficient and secure platform to share information with potential buyers or investors in a transparent way, and the process of due diligence could require huge amounts of data. Life science companies also make use of VDRs for everything from clinical trial data to HIPAA compliance documentation.

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